Mobile 3D Imaging of Arthritis ("Arthritis3D")
Research type
Research Study
Full title
Earlier identification and enhanced characterisation/quantification using Digital Tomosynthesis in the diagnosis of inflammatory arthritis (“Arthritis3D”).
IRAS ID
348373
Contact name
Karen M Knapp
Contact email
Sponsor organisation
University of Exeter
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Rheumatoid arthritis (RA) and other inflammatory arthritis (IA) types, like psoriatic arthritis (PsA), are chronic autoimmune diseases that mainly affect the joints, causing pain, swelling, and damage over time. Early diagnosis is crucial to prevent permanent joint destruction. Imaging techniques help doctors see the changes in joints and bones, guiding treatment decisions.
Traditional X-rays are commonly used because they are accessible and affordable. They can show joint space changes and bone damage, which are signs of advanced disease. However, X-rays often miss early inflammation, with up to 30% of early RA patients showing normal X-rays despite having significant inflammation.
Ultrasound (US) is better at detecting early signs of RA, like joint inflammation and damage, and can also show blood flow in the joints, which indicates active disease. However, its accuracy depends on the skill of the operator.MRI is considered the best tool for detecting early RA changes, providing detailed images of both bones and soft tissues. It can detect inflammation, bone damage, and cartilage loss, but it is expensive and must be interpreted alongside other tests to avoid misdiagnosis.
New technology, Adaptix 3D X-ray system, offers a cheaper and portable option. It uses Digital Tomosynthesis (DT) to create clearer images of bones and joints. This could help detect subtle joint changes earlier and improve treatment decisions. Although there is a small radiation risk from DT, it is minimal and well within safe limits.
This study will evaluate the Adaptix DT system in diagnosing, monitoring, and managing RA and IA compared to standard X-rays.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
25/YH/0032
Date of REC Opinion
10 May 2025
REC opinion
Further Information Favourable Opinion