Mitochondrial function in patients undergoing elective hip replacement
Research type
Research Study
Full title
Mitochondrial function at baseline: an observational study in patients undergoing elective hip replacement surgery.
IRAS ID
208220
Contact name
Daniel Martin
Contact email
Sponsor organisation
Royal Free Hospital Research and Development Office
Duration of Study in the UK
0 years, 7 months, 1 days
Research summary
More than 90% of human energy requirements are generated by mitochondria, tiny powerhouses that exist within almost every cell in the body. They require oxygen to convert carbohydrate, fat and protein into usable energy currency (ATP). Mitochondrial dysfunction has been implicated in many disease processes, from Alzheimer’s disease to atherosclerosis to aging, and has been associated with worse outcomes in critical illness. Understanding how mitochondrial dysfunction contributes to critical illness may reveal new therapeutic targets to improve clinical outcomes in these patients.
Assessing mitochondrial function is challenging. One approach uses tissue respirometry to assess the overall capacity and efficiency of intact mitochondria within their normal environment within cells. Little is known about what constitutes normal values for mitochondrial function as measured by tissue respirometry in adult humans. Establishing baseline values, across a wide range of ages and co-morbidities, but outside of the context of severe illness, will allow us to identify important differences in mitochondrial function that may contribute to critical illness and other active diseases.
The aim of this study is to establish the range of values for respirometry-derived measures of mitochondrial function that represents baseline function in systemically well adults across a range of ages and co-morbidities. The results will form a useful baseline with which to compare tissue respirometry values in patient cohorts defined by active disease states, such as critically ill patients. This information will complement our programme of translational research looking into mechanisms of mitochondrial dysfunction in the sickest patients.
This study will measure mitochondrial function using tissue respirometry in fresh skeletal muscle samples taken from patients undergoing elective hip replacement surgery at the Royal Free Hospital. Data will include measures of mitochondrial capacity and efficiency. Basic demographic information will also be collected, including the age, gender, co-morbidities, ASA and P-POSSUM scores of the subjects.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0317
Date of REC Opinion
7 Sep 2016
REC opinion
Further Information Favourable Opinion