MIS-ABC Sepsis (ENG)
Research type
Research Study
Full title
MIS-ABC Sepsis: Mechanistic Inflammatory Sub-study embedded in the Albumin versus Balanced Crystalloid in Sepsis trial – ABC Sepsis
IRAS ID
301333
Contact name
John (Jack) Cafferkey
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
0 years, 4 months, 1 days
Research summary
This is a sub-study looking to understand how the immune response in patients with infection changes during the early stages of the illness, as well as after intravenous fluid treatment. Participants in the main trial will be given one of two types of fluid (Human Albumin Solution (HAS) and Balanced Crystalloid) via a drip when they present to the hospital with severe infection (sepsis). The main trial is assessing which fluid is better, and we are going to take three blood samples around the time people come to hospital to see what happens to their immune system as a result of the infection and fluid treatment. We hope our findings will explain why one fluid might be better than another. It may also give us an important information about whether we can predict which people might get sicker despite treatment.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
21/NW/0200
Date of REC Opinion
15 Jul 2021
REC opinion
Favourable Opinion