miRNA role in endometrial receptivity
Research type
Research Study
Full title
The contribution of microRNAs to the embryonic – endometrial dialogue in normal & altered endometrial receptivity
IRAS ID
124027
Contact name
Tamer Nafee
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 11 months, 28 days
Research summary
Despite intensive research, the molecular events underlying successful implantation are far from being understood. An altered endometrial response to the developing embryo is thought to underlie clinical disorders of implantation, such as recurrent implantation failure (RIF) and Recurrent Early Pregnancy Loss (REPL). MicroRNAs have newly characterized key players in intracellular control of gene expression, protein production and in intercellular communication. They can simultaneously target a multitude of genes and pathways and are ideally suited to orchestrate mass responses inside cells. We hypothesize that microRNAs play a key role in mediating baseline endometrial receptivity and normal endometrial response to the developing embryo, and that they are altered in disorders of abnormal endometrial receptivity.
This project aims to:
1.Characterize the microRNA output of receptive human endometrium versus human endometrium from patients diagnosed with RIF and REPL (Baseline Profiling) and,
2.Characterize the normal and abnormal patterns of microRNA – mediated response of endometrial cells to the embryonic challenge (Dynamic Profiling) and correlate the microRNA profiles with their respective transcriptomic and proteomic profiles.REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
15/EE/0058
Date of REC Opinion
15 Jun 2015
REC opinion
Further Information Favourable Opinion