MIPA
Research type
Research Study
Full title
Preoperative Breast MRI in Clinical Practice: Multicenter International Prospective Meta-Analysis (MIPA) of Individual Woman Data An EIBIR-EuroAIM/EUSOBI Study
IRAS ID
133294
Contact name
Fiona J Gilbert
Contact email
Sponsor organisation
European Institute for Biomedical Imaging Research
Research summary
Breast cancer is the second most common cancer in women with a 5 year survival rate of 80%. Many studies showed that breast conserving treatment when compared with mastectomy, has the same survival rate but has a higher rate of ipsilateral recurrence. Breast MRI has been demonstrated to out-perform mammography and ultrasonography in evaluating index tumour size as well as in detecting additional ipsilateral and contralateral tumours, showing otherwise undetected multifocal/multicentric and contralateral cancers. In some centers an increased rate of mastectomies has been observed with the use of preoperative MRI. Thus, preoperative MRI has become one of the most debated management topics in the breast cancer literature.
The results of two randomised controlled trials (RCTs) concerning preoperative MRI were recently published, neither of them in favour of the use of preoperative breast MRI. The results of both RCTs were unexpected and have not definitively solved the clinical issue of using or not using MRI for a preoperative evaluation of breast cancer. Notwithstanding these results and recommendations, preoperative breast MRI is increasingly used in clinical practice. Thus, a systematic evaluation of preoperative breast MRI looking at the individual patient data in a multicentre international setting could clarify the above matters regarding the ongoing uncertainty on application of preoperative MRI.
The aims of this study are to prospectively and systematically collect data on consecutive series of women with a newly diagnosed first breast cancer who are being treated with surgery. Data on surgical outcomes for the MRI group with those obtained for the concurrent no MRI group, matched for age (5-year age group strata) will be collected and analysed.
REC name
North of Scotland Research Ethics Committee 1
REC reference
13/NS/0104
Date of REC Opinion
11 Sep 2013
REC opinion
Further Information Favourable Opinion