MINST in teeth with unfavourable prognosis
Research type
Research Study
Full title
Clinical and radiographic changes following minimally-invasive non-surgical therapy in teeth with unfavourable prognosis. A pilot prospective cohort study.
IRAS ID
265686
Contact name
Luigi Nibali
Contact email
Sponsor organisation
Vice President & Vice Principal (Research). King's College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
3 years, 9 months, 31 days
Research summary
The main aim of this study is to assess the efficacy of a minimally-invasive non-surgical periodontal therapy (MINST) for the treatment of teeth with unfavourable periodontal prognosis. Therefore patients presenting with: i) molars with grade II C furcation involvement and ii) teeth with periodontal attachment and bone loss to the apex will be offered participation in the study that will take place at Guy's Hospital. This type of intervention differs from the conventional approach in that the treatment of the root surface is exclusively done with piezo-electric devices with specific thin and delicate tips to minimise the trauma to the gum that is normally associated with the standard technique and avoiding subgingival rinses to favour the formation of a stable blood clot. It has been hypothesised that this type of intervention seems to improve the blood flow and help the stabilisation of the blood clot in the bony defect, resulting in better clinical and radiographic outcomes when compared to conventional technique in these type of compromised teeth. The duration of the study will be 46 months from first patient first visit to last patient last visit and data analysis. During this period the subjects will receive the following procedures: Initial dental/periodontal examination, clinical photographs, radiographic examination, MINST on selected teeth as part of their overall periodontal treatment, saliva/gingival crevicular fluid/subgingival plaque sampling and patient-reported outcomes questionnaires. Data will be analysed and a report will be submitted as required 12 months after the clinical visits are completed. However, further analysis may need to continue after these 12 months.
REC name
London - Bromley Research Ethics Committee
REC reference
19/LO/1819
Date of REC Opinion
20 Dec 2019
REC opinion
Further Information Favourable Opinion