Minocycline and Depression (MINDEP) study
Research type
Research Study
Full title
Understanding the molecular basis for the use of adjunctive anti-inflammatory treatment in treatment resistant depression: a stratified, randomised, placebo-controlled, experimental medicine study using minocycline.
IRAS ID
189324
Contact name
Valeria Mondelli
Contact email
Sponsor organisation
King's College London
Eudract number
2015-003413-26
Duration of Study in the UK
1 years, 10 months, 1 days
Research summary
Scientists have found that the immune system, which is the system dedicated to fight infections in our body, is in a state of "hyperactivity" in patients with depression (also called "inflammation"), as if they were fighting an infection, even though they do not have an ongoing infection. The main aim of the project is to investigate the association between changes in inflammation and the improvement of depression, following treatment with minocycline (alongside the regular antidepressant) in treatment-resistant depressed patients selected for increased inflammation levels.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
15/LO/1907
Date of REC Opinion
13 Nov 2015
REC opinion
Favourable Opinion