Minimally invasive kidney transplantation
Research type
Research Study
Full title
Minimally invasive kidney transplantation: Surgical stress and kidney injury.
IRAS ID
184202
Contact name
Nizam Mamode
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Kidney transplantation is the optimal treatment for end stage renal failure. The operation has changed little since it was first performed 50 years ago. New innovations in minimal access surgery have transformed other fields of surgery and are being introduced to kidney transplantation. Robotic surgery is a form of minimally invasive surgery that has the potential to reduce the surgical stress of open kidney transplantation. It however may increase the potential kidney injury associated with transplantation by prolonging the warm ischaemia time (the time it takes to reperfuse the donor kidney with blood). The consequences of this for the function of the transplant are not known.
This study aims to investigate the effect of the anticipated longer warm ischaemia time on kidney injury by measuring biomarkers of kidney injury which are found in blood and urine to establish if there is a significant difference between robotic and open surgery. The study will also investigate the potential benefits of minimally invasive surgery on the surgical trauma associated with open surgery by assessing the surgical stress response and wound healing between both groups of transplant patients and also compared with donors.
The study will be conducted on an observational case-control basis comparing groups of patients receiving standard care in three arms: open living donor kidney transplantation, robotic living donor kidney transplantation and laparoscopic donor nephrectomy. Samples of blood and urine will be collected in the first post-operative week alongside the routine clinical sampling from the first two groups only. The participants will undergo an ultrasound scan of their surgical incision at 3 times points post transplant. The study will last for 1 year and the participants are not expected to any extra clinical interventions or visits other than their standard clinical care.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
18/SC/0027
Date of REC Opinion
10 Jan 2018
REC opinion
Favourable Opinion