MiniEx in Diabetes
Research type
Research Study
Full title
Determining the minimum amount of exercise to improve glycaemic control in young and old overweight males, and in patients with type II diabetes
IRAS ID
248319
Contact name
Christopher J Gaffney
Contact email
Sponsor organisation
Lancaster University
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Type II diabetes is a major healthcare burden and exercise is effective in both preventing diabetes and treating diabetes. Despite the knowledge that exercise in different forms, such as resistance exercise (e.g. weights), high intensity interval training (e.g. repeated sprint exercise) and endurance exercise (e.g. long distance running), improve the control of blood sugar levels, the minimum amount of exercise required to improve the control of blood sugar has not been established. This study will recruit young and older overweight and obese volunteers who do not have diabetes and overweight volunteers that do have type II diabetes matched to the 'older' group. . These individuals will undergo a no exercise visit, and three exercise visits where the exercise duration is changed so that the volunteer expends 175kcal, 350kcal, or 700kcal of energy during exercise. The day after exercise, a test will be completed to determine how well the body controls blood sugar levels. The prediction is that the greater energy expenditure visit (i.e. 700kcal) will improve control of blood sugar levels to a greater extent than the lower energy expenditure visit (i.e. 175kcal). Collectively, we can use these data to predict the change in blood sugar levels that results from any amount of exercise. This allows us to calculate the minimum amount of exercise someone can complete to control blood sugar and avoid type II diabetes. There is a progressive loss of muscle structure and function with age, which is known as sarcopenia, and this leads to a greater threat of developing type II diabetes as we get older. This study will also determine if older individuals need more exercise to control blood sugar and avoid type II diabetes. We will determine this through comparing the exercise requirements in younger and older BMI-matched volunteers.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
19/NW/0066
Date of REC Opinion
5 Jun 2019
REC opinion
Further Information Favourable Opinion