MINI Study
Research type
Research Study
Full title
Molecular Imaging of NeuroInflammation (MINI) Study
IRAS ID
300131
Contact name
Jonathan Rohrer
Contact email
Sponsor organisation
University College London Hospitals NHS Trust (UCLH) / UCLH/UCL Joint Research Office, part of the Research Directorate
Clinicaltrials.gov Identifier
Z6364106 2022 02 41, UCL Data Protection Registration
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
This study is a cohort study investigating neuroinflammation in frontotemporal dementia (FTD) using positron emission tomography (PET) imaging. There are currently no effective treatments for FTD, and the nature and sequence of pathogenic events leading to disease onset in FTD are not yet clear. However, recent evidence suggests that dysregulation of neuroinflammatory mechanisms (e.g. chronic inflammation) may be involved in the disease process, and yet few studies to date have examined neuroinflammatory pathways in FTD.
[18F]-DPA-714 is a PET tracer of microglial activation which measures neuroinflammation in vivo. This study will use [18F]-DPA-714 PET to measure the extent and distribution of neuroinflammation in people with FTD, as well as those in the presymptomatic period of disease. Understanding the role of neuroinflammation in FTD will help to elucidate disease mechanisms, provide a potential biomarker of disease-related change and identify treatment targets.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
22/LO/0707
Date of REC Opinion
12 Dec 2022
REC opinion
Further Information Favourable Opinion