Mini-Fluid bolus
Research type
Research Study
Full title
Use of a mini-fluid bolus to identify Fluid Responsiveness
IRAS ID
215712
Contact name
Andrew MacDuff
Contact email
Sponsor organisation
Royal Wolverhampton NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The aim of this study is to see if giving a small amount of fluid to a critically ill patient and measuring its effect on the amount of blood pumped by the heart can be used to predict a significant improvement in cardiac output after the administration of a larger bolus. This is an important question as the administration of large volumes of fluid to resuscitate patients is a cornerstone of Intensive Care Medicine. However the accurate identification of patients who will benefit from more fluid rather than other approaches (e.g. vasoconstrictor drugs) is very challenging and many of the tools currently used are imperfect.
By using a special monitor that can measure the amount of blood pumped by the heart we will look to see if we can identify those who would benefit from a fluid bolus by measuring the response to a series of smaller (50ml) boluses. If possible then this will let us guide fluid therapy better in a challenging group of patients.REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
17/WM/0344
Date of REC Opinion
22 Jan 2018
REC opinion
Further Information Favourable Opinion