MINERVA UK Multicentre Investigation
Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction – UK multicentre collaboration "MINERVA"
G. Andre Ng
University of Leicester
Duration of Study in the UK
3 years, 0 months, 0 days
Sudden cardiac death (SCD) is responsible for over 3 million deaths worldwide annually. These deaths could be prevented with implantable cardioverter defibrillators (ICDs). Choosing appropriate patients for ICDs can be extremely difficult, leading to patients who we think are “high-risk” receiving ICDs without ever using them, while the majority of SCD occurs in a large population regarded as “low-risk”.
At Leicester we have developed the Regional Restitution Instability Index (R2I2) and Peak ECG Restitution Slope (PERS). These are numerical values of cardiac risk, based on the electrocardiogram (ECG) which is a simple everyday test performed to record the rhythm and electrical activity of the heart. R2I2 and PERS take into account subtle differences in the electrical properties around different regions of the heart. We have already shown these tools to be effective in a series of small studies performed at Leicester that were recently published.
The study will recruit patients from the some of the UK’s leading specialist cardiac centres. Suitable patients will include those enlisted for ICD implants who also have ischaemic heart disease (caused by narrowing of arteries). Entering the study will involve an extra test performed during ECG recording at the time of ICD implant via the ICD device itself. The test is not painful, will not involve extra visits to the hospital and will take around 20 minutes to perform. The stored data is analysed to calculate R2I2 and PERS and values are later correlated with patient outcomes.
R2I2 and PERS are simple and inexpensive to perform. If the findings from our previous studies are replicated, we will move closer to being able to incorporate them into clinical practice. Implementing these tests in patients being considered for ICDs has the potential to save lives and reduce the burden of harm and cost by improving the allocation of ICDs.
HSC REC B
Date of REC Opinion
17 May 2016
Further Information Favourable Opinion