MINDS
Research type
Research Study
Full title
Motion adaptive deep brain stimulation for MSA
IRAS ID
271719
Contact name
Alexander L Green
Contact email
Sponsor organisation
Clinical Trials and Research Governance
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 3 months, 1 days
Research summary
Patients referred to our department routinely and safely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson’s disease.
In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), the effects on autonomic parameters such as blood pressure and bladder symptoms has been shown to be improved by our group (unpublished data). In this current study, we plan to use a novel technique of adaptive DBS in order to provide stimulation dependent on patient physiological or positional factors. This will make stimulation more responsive and patient specific.
Our key goal is to:
Prove that a patient and physiology-specific DBS system that can adapt to changes in the patient is able to give at least as good an improvement in quality of life and physiological parameters as standard DBS.REC name
London - Stanmore Research Ethics Committee
REC reference
20/LO/1034
Date of REC Opinion
27 Oct 2020
REC opinion
Further Information Favourable Opinion