MIDNIGHT
Research type
Research Study
Full title
Maintenance In-Centre Nocturnal Haemodialysis: A Pilot Study Investigating the Effects on Cardiac Structure and Physical Function
IRAS ID
178400
Contact name
James Burton
Contact email
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
WHY?: Patients receiving haemodialysis usually have treatment in purpose built centres over four hours, three times a week. Due to the short haemodialysis sessions, fluid is removed from the body quickly; causing damage to the heart. Longer haemodialysis sessions can reduce this damage but are difficult to incorporate due to scheduling. One potential solution is to conduct the sessions overnight, however the Leicester General Hospital (LGH) is the only NHS centre currently doing this. This in-centre nocturnal haemodialysis (INHD) programme has been proven to be a viable service and, more importantly, found acceptable by patients.
WHAT?: This feasibility study will inform the design of a future randomised-controlled trial assessing the benefits of INHD. We will collect a number of outcomes including:
- Cardiovascular structure using magnetic resonance imaging (MRI).
- Heart function using a non-invasive bedside machine.
- Habitual activity levels using accelerometry.
- Body composition using a non-invasive bedside machine.
- Physical function using quick and simple field tests.
- Quality of life using questionnaires.
- Cardiovascular risk and damage by a 30ml (two tbspns) blood sample.WHO?: We will ask 10 patients currently receiving regular day time haemodialysis in the Leicester dialysis network to switch to INHD. We will also ask 10 similar patients to act as a comparison group, whilst remaining on daytime haemodialysis.
WHERE/HOW?: Established adult haemodialysis patients (i.e. on haemodialysis longer than 3 months and over 18 years old) will be approached at their dialysis unit. Patients providing ongoing informed consent will be in the study for 6 months. Assessments will be conducted at baseline, after three months and at the end of the study. Each time point requires 2-4 visits, depending on patient preference, either at the haemodialysis unit or the Glenfield General Hospital (only for MRI at baseline and end of study).
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
15/EM/0268
Date of REC Opinion
9 Jul 2015
REC opinion
Further Information Favourable Opinion