MIDAS-RTI - impact of diagnostics on antibiotics

• Research type

  Research Study

• Full title

  MIDAS-RTI: Measuring the impact of Improved Diagnostics on Antimicrobial Stewardship in Respiratory Tract Infection

• IRAS ID

  246355

• Contact name

  Kate Templeton

• Contact email

  kate.templeton@luht.scot.nhs.uk

• Sponsor organisation

  NHS Lothian

• Duration of Study in the UK

  3 years, 4 months, 31 days

• Research summary

  There is an international drive to simplify antibiotic treatments to stop side effects from antibiotics and to stop the development of superbugs.
  Pneumonia is an infection of the lung affecting 5 to 11 people out of 1,000 in the population in the UK. About 9% of patients admitted to hospital with pneumonia will die. Prompt and appropriate antibiotic treatment is needed to cure the
  pneumonia. International guidelines suggest using a combination antibiotic treatment for 7 to 10 days for patients admitted with pneumonia. However antibiotics given and for how long are often a best guess and not targeted to the what is actually causing the infection.

  Tests currently used in the NHS can identify the cause of pneumonia in 1 out of 3 patients. In addition, traditional methods to investigate pneumonia in the NHS take too long to give an answer.
  We have developed a molecular test that identifies the cause of pneumonia 9 out of 10 patients. Our test is very quick and we can have a result within a few hours. we call the test MiCAP.
  We will invite patients who have been admitted to hospital with pneumonia and have had specific sample already taken ( sputum) to enrol onto our study. Participants will be randomised to receive either (1) the usual NHS tests and normal treatment for pneumonia, or (2) the novel rapid test MiCAP and then customise antibiotic treatment.
  The main aim of the study is to determine if the MiCAP test can reduce the amount of antibiotics prescribed without any undesirable clinical side effects. We will assess if the new test changed antibiotic use and count up how much antibiotic treatment each participant had, including any additional antibiotics that might have been needed after initial treatment.

• REC name

  South East Scotland REC 01

• REC reference

  18/SS/0093

• Date of REC Opinion

  24 Aug 2018

• REC opinion

  Further Information Favourable Opinion