MIDAS-HEART
Research type
Research Study
Full title
A Study to Evaluate the Relationship between Cardiac Microvascular Dysfunction, Diabetes and Cardiac Structural and Functional Abnormalities
IRAS ID
348083
Contact name
Ify Mordi
Contact email
Sponsor organisation
University of Dundee
Duration of Study in the UK
5 years, 0 months, 2 days
Research summary
Heart failure (HF) outcomes are worse in people with type 1 (T1D) and type 2 diabetes (T2D) than in those without diabetes. Research in this area is however lacking, and where present has primarily focused on T2D. There is limited understanding of the pathophysiology of HF in T1D despite its poor prognosis.
The overall aim of MIDAS-HEART is to address this knowledge gap in prevention and treatment of HF in individuals with T1D. I hypothesise that the presence of cardiac microvascular disease (MVD) may play an important role in the pathophysiology and outcomes of HF in T1D. In my proposed program of patient-centred research I will conduct a prospective observational study to explore the pathophysiological role of cardiac MVD in patients with T1D and HF using a comprehensive assessment of cardiac imaging in people with and without T1D and HF. This study will address a significant unmet need, providing novel insights into HF in T1D that may support improved prevention and treatment of HF in T1D in future.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
24/ES/0092
Date of REC Opinion
13 Jan 2025
REC opinion
Further Information Favourable Opinion