Microthin DSAEK vs DMEK - RCT

• Research type

  Research Study

• Full title

  Microthin corneal endothelial keratoplasty (MT DSAEK) versus Descemets’ membrane endothelial keratoplasty (DMEK): A randomized clinical trial of corneal transplant outcomes and visual function

• IRAS ID

  201097

• Contact name

  Madhavan Rajan

• Contact email

  madhavan.rajan@addenbrookes.nhs.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust

• Duration of Study in the UK

  0 years, 11 months, 31 days

• Research summary

  Corneal disorders resulting in corneal opacification is a significant cause of blindness in the UK and remains the second commonest cause of blindness in developing world. Recent innovations in corneal transplant techniques (Endothelial keratoplasty) had shown significant benefit to patients in relation to visual function, rapid post -operative recovery, minimal hospital stay and fewer complications. Endothelial transplants are prepared from human cadaveric donor corneas either using a mechanized microkeratome (Microthin DSAEK) or by manual dissection (DMEK) with variations in surgical technique. So far, there has not been an attempt in literature to compare Microthin DSAEK with DMEK. It is important to establish the clear benefit between these two techniques in order to provide informed choices to patients, surgical teams and eye banks.

• REC name

  London - Fulham Research Ethics Committee

• REC reference

  16/LO/1343

• Date of REC Opinion

  21 Jul 2016

• REC opinion

  Favourable Opinion