MicroRNA Expression and Function in Psoriasis III
Research type
Research Study
Full title
MicroRNA Expression and Function in Psoriasis III
IRAS ID
191862
Contact name
Kehinde Ross
Contact email
Sponsor organisation
Liverpool John Moores University
Duration of Study in the UK
2 years, 2 months, 13 days
Research summary
Are the levels of miRNAs and related proteins altered in psoriatic skin?
Although new treatments for severe psoriasis have been developed, there remains an unmet need for effective interventions for the mild or moderate disease typically seen in clinics. Small RNA molecules known as microRNAs control the levels of numerous biomolecules in cells. Some of these biomolecules, including members of the Argonaute family, block cell growth at a genetic level. However, the relationship between psoriasis, psoriatic microRNAs and Argonautes has not been established. Using samples from lesional and non-lesional psoriatic skin, we will test the idea that Argonautes are depleted in psoriatic lesions and this reduction in Argonaute expression may be linked to the unchecked cell growth associated with the disease. Together, with additional laboratory investigations, these studies will support the development of microRNA-based therapy for psoriasis.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
15/WM/0388
Date of REC Opinion
20 Oct 2015
REC opinion
Favourable Opinion