Microfluidic devices to assess viral infections
Research type
Research Study
Full title
Application of microfluidics for the maintenance of Glioblastoma multiforme biopsies and testing their response to SARS-COVID19
IRAS ID
318710
Contact name
John Greenman
Contact email
Sponsor organisation
University of Hull
Duration of Study in the UK
1 years, 9 months, 28 days
Research summary
A miniature device has been developed by the University of Hull to maintain whole biopsies of tumour viable and functional for more than eight days. The aim of the current application is to investigate how SARS-CoV-2 and other similar viruses can cross biological barriers and affect the biology of organs such as the brain.
The effects of the viral agents on the tumour will be assessed in isolation and in connection with other devices that model additional organs such as the gut and the lungs to assess the effect of these viral agents on an integrated human system. The lung tissue will come from collaborators who have ethical approval to remove such tissue.
A key part of the project is to transfer tissue, and functional Microfluidics devices, between UKHSA and the Quadram Institute.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
23/YH/0011
Date of REC Opinion
14 Feb 2023
REC opinion
Further Information Favourable Opinion