Microfluidic device for Gut-Brain studies
Research type
Research Study
Full title
Dual flow microfluidics for the modeling of the gut-brain axis to evaluate the effect of inflammatory mediators delivered via micro-particles to the gut and subsequently effects on the blood brain barrier.
IRAS ID
221272
Contact name
John Greenman
Contact email
Sponsor organisation
Hull & East Yorkshire NHS Trust
Duration of Study in the UK
2 years, 5 months, 31 days
Research summary
A dual flow device has been developed that can keep a whole piece of gut tissue alive for several days. In this study we wish to extend the study through the addition of microparticles (small lipid bound vesicles with a diameter less than one micron), derived from various cell types, to tissue samples maintained in devices to test for inflammatory responses. In addition, a secondary chip mimicking the blood brain barrier will be connected in series via tubing. this will allow the relationship between the gut and the brain to be studied. By analysing tissue from inflammatory bowel disease and histologically normal samples the effects of health of the gut on the brain can be assessed.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
17/EM/0207
Date of REC Opinion
15 Jun 2017
REC opinion
Further Information Favourable Opinion