Micro-perimetry in glaucoma
Research type
Research Study
Full title
The effect trabeculectomy surgery on the central visual field in participants with glaucoma and an established central visual field defect using Micro-perimetry and Optical coherence tomography.
IRAS ID
161709
Contact name
John Salmon
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Glaucoma affects more than 67 million people worldwide, of which 10% are estimated to be blind (Quigley, 1996). Glaucoma is the leading cause of irreversible blindness worldwide.
Peripheral vision is usually affected first, whilst central vision is relatively spared until late in the disease. In some types of glaucoma the central vision can be affected early, which leads to significant visual disability for patients, particularly if affecting both eyes.
Mirco-perimetry (MP) is a non-invasive method to map the central visual field and determine both the extent and density of defects. MP provides a more in depth measure of visual field than traditional field testing due to the ability of the machine to track eye movements and adjust the testing position accordingly.
Optical coherence tomography (OCT) is a non-invasive imaging modality that is commonly used to objectively assess the structural integrity of both the optic disc and macula.
Patients with advanced glaucoma will have MP and OCT carried out during the first 3 months after glaucoma surgery. This will be a prospective, observational case series with potential participants identified during attendance in the glaucoma clinics. . Patients listed for trabeculectomy surgery will have MP and OCT scan pre-operatively, at 1 month and 3 months post-operatively. The study is funded by Mr Salmon's research fund.
The main stay of treatment for glaucoma is drops to try to reduce the pressure inside the eye. If the disease is advanced and/or progressing, surgery maybe required. Micro-perimetry can be used to map the central visual field in detail.
We plan to observe how the central visual field defect changes in the first few months in patients requiring trabeculectomy surgery for glaucoma. This will help doctors best advise their patients about the benefits and risks of trabeculectomy surgery.
REC name
North West - Haydock Research Ethics Committee
REC reference
15/NW/0231
Date of REC Opinion
24 Mar 2015
REC opinion
Further Information Favourable Opinion