Mi-AF
Research type
Research Study
Full title
Mechanisms of myocardial injury and ischemia in patients with rapid Atrial Fibrillation
IRAS ID
340518
Contact name
Nicholas Mills
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
Duration of Study in the UK
4 years, 6 months, 1 days
Research summary
Rapid atrial fibrillation (AF) is a condition with a fast, irregular heartbeat. It is the most common heart problem in older people and increases the risk of heart attack, stroke and death.
Patients who come to the emergency department with rapid AF can have symptoms of chest pain and shortness of breath. It can be difficult to tell if the symptoms are due to their fast heartbeat from AF, undiagnosed narrowing of heart arteries (coronary artery disease), damage to the heart (myocardial injury) or a combination of all three. Troponin (a protein measured by a blood test) can be used to detect damage to the heart but it isn't known if measuring troponin in patients with AF will always be useful to detect that damage. Troponin might also be able to predict if there is coronary artery disease and help recommend patients for further investigations.
This study (Mi-AF) is a multi-centre observational cohort study that aims to understand if measuring troponin in patients rapid AF will be useful. To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI) to see if the heart is not getting enough oxygen (myocardial ischemia).
We aim to understand if:
1. Patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) are more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease)
2. Patients with rapid AF and myocardial injury with evidence of that their heart hasn't been getting enough oxygen(myocardial ischemia) are more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia.REC name
South East Scotland REC 02
REC reference
25/SS/0009
Date of REC Opinion
5 Feb 2025
REC opinion
Further Information Favourable Opinion