Metabolomics in SLE
Research type
Research Study
Full title
Pilot study on the use of metabolomics to predict outcome in patients with systemic lupus erythematosus
IRAS ID
154850
Contact name
Caroline Gordon
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
We aim to assess the potential of metabolic fingerprinting in lupus to predict future life-threatening complications. We will use NMR-based metabolomics to analyse serum and urine samples from a well-established lupus cohort. Samples from recently diagnosed lupus patients at baseline and time of flare, and serial samples from patients with a history of lupus nephritis and neuropsychiatric lupus (before and after flare), will be studied as well as serial samples from patients with atherosclerotic events and matched lupus patients without these complications. Identification of different profiles may enable the identification of patients at risk of life-threatening complications early in the disease course and may increase understanding of important metabolic pathways with potential for the design of new therapies for lupus.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
15/WM/0200
Date of REC Opinion
3 Jul 2015
REC opinion
Favourable Opinion