Metabolism after surgery v.1
Research type
Research Study
Full title
The metabolic consequences of gastrointestinal surgery
IRAS ID
194370
Contact name
Geoffrey Roberts
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Clinicaltrials.gov Identifier
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Surgery to remove or bypass the stomach is known to cause significant changes in how the body processes food, particularly altering the effect of insulin on sugar levels. After bariatric surgery this often results in remission of diabetes, after cancer surgery more often disabling post-prandial symptoms caused by low blood sugar (called "dumping syndrome"). We believe that the study of how the body's ability to sense and process food after surgery will lead us to better therapies for the deleterious symptoms, and positive metabolic effects of surgery. We will combine the study of eating behaviour indices (using online questionnaires), how the food sensing cells of the gut alter their behaviour after surgery (by collecting and processing intestinal samples from patients) and how the body responds to food (using sugar tolerance tests with measurement of key hormones produced by the body). We aim to advance our understanding of the metabolic consequences of surgery, define new approaches to the diagnosis and management of dumping syndrome, and improve our knowledge of human gastrointestinal and metabolic physiology.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0338
Date of REC Opinion
28 Nov 2016
REC opinion
Further Information Favourable Opinion