META-CYTE
Research type
Research Study
Full title
Metabolic Profiling of Circulating Myeloid Cells during ARDS – The Meta-Cyte Study
IRAS ID
234696
Contact name
David Griffith
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
1 years, 1 months, 1 days
Research summary
Patients treated in intensive care or high dependency units often have a condition called adult respiratory distress syndrome (ARDS). This condition is characterised by ‘inflammation’ of the lungs – when the lungs become fluid filled and heavy resulting in problems with breathing and delivery of vital oxygen to the other vital organs in the body. ARDS can be very dangerous and patients that have this condition require special monitoring and treatment. Although research has shown that the damage that occurs in the lung during ARDS is driven by numerous factors, there are still many unanswered questions. There are as yet no treatments for ARDS.
The white blood cells (part of the body’s immune system) are likely to be important in ARDS and laboratory studies have shown that low oxygen levels (often seen in ARDS) can change the way the white blood cells work. It is important to find out if the observations made in the laboratory are also seen in patients with this condition as greater understanding of these changes will inform the development of better treatments. The Meta-Cyte study, is therefore a blood sampling study, to explore whether the function of white blood cells changes during ARDS, and whether these changes are reversed during recovery.
REC name
Scotland A: Adults with Incapacity only
REC reference
17/SS/0136
Date of REC Opinion
5 Jan 2018
REC opinion
Further Information Favourable Opinion