MET-REPAIR v1.0

• Research type

  Research Study

• Full title

  MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR): a prospective, multi-centre cohort observational study

• IRAS ID

  230488

• Contact name

  Simon Howell

• Contact email

  S.Howell@leeds.ac.uk

• Sponsor organisation

  University of Leeds

• Clinicaltrials.gov Identifier

  NCT03016936

• Clinicaltrials.gov Identifier

  NCT03016936, ClinicalTrials.gov Identifier

• Duration of Study in the UK

  0 years, 11 months, 30 days

• Research summary

  This study seeks to investigate the prognostic value of estimation of a patient's exercise capacity prior to major non-cardiac surgery. Current guidance from the European Society of Anaesthesia and European Society of Cardiology, American College of Cardiology and American Heart Association recommends that patients’ exercise capacity should be estimated in terms of metabolic equivalents (METs). The number of METs reflects the increase in oxygen consumption during an activity compared to when at rest. For example, if 1 MET equates to a patient at rest and 4 METs is walking up two flights of stairs, the latter activity requires four times as much oxygen consumption.
  The primary objective is to determine whether the number of METs a patient can achieve, as estimated using a questionnaire, is associated with major adverse cardiovascular events or cardiovascular mortality around the time of surgery, and if so, what is the value for METs that can best predict whether a patient will suffer these complications?
  In a substudy, the patient’s NTproBNP (N-Terminal prohormone of Brain Natriuretic Peptide) level will be measured to determine whether NTproBNP improves prediction of perioperative cardiovascular events and cardiovascular mortality when added to clinical data and estimated METs.
  If such associations exist, they will add to the methods available for establishing patients’ risk of morbidity or mortality when they undergo major surgery.

  This study will include participants of 45 years of age or older undergoing planned high-risk non-cardiac surgery or 65 years and older undergoing intermediate or high-risk procedures. Participants will complete a questionnaire to estimate their exercise capacity prior to surgery and may have a blood sample taken. Observational outcome data will subsequently be collected after surgery. This multicentre, international study aims to recruit 15,000 participants. It is anticipated that a number of UK centres will recruit patients for this study.

• REC name

  London - Westminster Research Ethics Committee

• REC reference

  18/LO/1081

• Date of REC Opinion

  2 Jul 2018

• REC opinion

  Favourable Opinion