Meso-ORIGINS Feasibility Study
Research type
Research Study
Full title
Meso-ORIGINS Feasibility Study
IRAS ID
253522
Contact name
Kevin Blyth
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Pleural Mesothelioma is a type of cancer that affects the lining of the lung and is associated with asbestos exposure. Mesothelioma is unique in that it occurs many decades after exposure to asbestos dust and the period between exposure and cancer development is frequently associated with intense inflammation in the pleura (the lining of the lung, where Mesothelioma most frequently develops). At present, it is not known what triggers the change from benign pleural inflammation to Mesothelioma. We have developed an ambitious study called Meso-ORIGINS to define this, allowing development of more effective treatments and earlier interventions for the disease. We have in place an expert group of researchers to deliver Meso-ORIGINS but first need to show that the new methods we plan to use are feasible, before we can apply for a large grant to fund the study. Specifically, the current feasibility study will test a) whether it would be possible to recruit enough patients in a reasonable amount of time and b) how many patients we would require. This will be done by asking potentially eligible patients if they would consent to what is proposed and by using ultrasound scans to work out if repeat biopsies would be possible. The participants will be involved in the study for a maxiumum of 6 months and will attend hospital twice in this time for hospital outpatient clinic visits where the study information will be collected. There are no invasive procedures involved in this. Patients will be recruited for the study from 4 different UK specialist centres (Glasgow, Oxford, Manchester and Bristol) and identified at clinic appointments following the biopsies. We will also collect data from these 4 centres from electronic databases (restrospective database study) to work out the numbers of patients needed for and to try to identify predictors of mesothelioma.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
18/SC/0617
Date of REC Opinion
7 Nov 2018
REC opinion
Favourable Opinion