MeSenteric SpAring Versus High Ligation Ileocolic Resection in Crohn's

• Research type

  Research Study

• Full title

  MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn’s DiseaSe (SPARES)

• IRAS ID

  293249

• Contact name

  Sunder Chita

• Contact email

  sunderchita@nhs.net

• Sponsor organisation

  London North West University Healthcare NHS Trust

• ISRCTN Number

  ISRCTN15740250

• Clinicaltrials.gov Identifier

  NCT04578392

• Duration of Study in the UK

  5 years, 0 months, 1 days

• Research summary

  There is increasing evidence to suggest that the mesentery may play an active role in the pathophysiology of Crohn’s disease. There is significant clinical, endoscopic, and surgical recurrence of disease following ileocolic resection at the site of the anastomosis. We are seeking to understand if the mesentery plays a role in recurrence following ileocolic resection. Patients will be randomized according to post-operative recurrence risk to either a high ligation of ileocolic artery or mesenteric sparing ileocolic resection for terminal ileal Crohn’s disease. The primary endpoint 6-month endoscopic recurrence. We do this to find a way to reduce the recurrence rate after ileo-colic resection.
  

• REC name

  South East Scotland REC 01

• REC reference

  21/SS/0039

• Date of REC Opinion

  4 Jun 2021

• REC opinion

  Further Information Favourable Opinion