Mental ill-health impact on medication adherence in heart failure
Research type
Research Study
Full title
Exploring the impact of improving mental health on heart failure prognosis and adherence to treatment behaviour in primary care based patients.
IRAS ID
261540
Contact name
Hana Morrissey
Contact email
Sponsor organisation
University of Wolverhampton
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
1 years, 6 months, 16 days
Research summary
In the UK, Heart Failure (HF) is a significant and rising public health problem affecting approximately 920,000 people. The incidence of HF increases with age; the average age of diagnosis is roughly around 75 years old. HF accounts for 5% of all UK emergency department admissions.
HF can result from structural or functional cardiac disorders leading to inadequate cardiac function and physiological changes which do not meet the body’s demands.
HF as a long-term condition can affect patient’s wellbeing in many ways; depression and anxiety are the main two conditions reported. There is insufficient data to explain whether there is a direct or indirect relationship between the three elements; mental illness, HF symptom control and patients’ ability to adhere to their treatment.
Both conditions can be treated by non-pharmacological and/or pharmacological therapy. Examples of non-pharmacological interventions include smoking cessation, alcohol intake reduction, stress management, diet and physical activities.
This study aims to assess the effects of mental ill-health on patients with HF and their behaviour regarding to adherence to HF therapy.
We will recruit people diagnosed with HF and using questionnaires which will screen them for medication adherence behaviour, depression and anxiety. We will review medications for HF and other conditions including mental illness. We will use their baseline adherence to therapy score, the level of cortisol, which is related to the level of depression in their saliva and the level of brain-natriuretic peptide (BNP) in their blood, which is related to their heart health, to explore if improving medication adherence, through improving mental health has an impact on heart health and their overall health outcomes.REC name
North West - Liverpool Central Research Ethics Committee
REC reference
19/NW/0509
Date of REC Opinion
4 Sep 2019
REC opinion
Further Information Favourable Opinion