Meniscal Tear and Osteoarthritis Risk (MenTOR)
Research type
Research Study
Full title
Does the biological response to degenerate meniscal tears, or to their intervention, predict future osteoarthritis? The Meniscal Tear and Osteoarthritis Risk (MenTOR) study.
IRAS ID
173428
Contact name
Fiona Watt
Contact email
Sponsor organisation
Buckinghamshire NHS Trust
Duration of Study in the UK
7 years, 11 months, 31 days
Research summary
The aim of this research is to identify molecules in the synovial fluid which predict osteoarthritis (OA) following chronic damage to the meniscus (one of 2 c-shaped cartilages in the knee) in adults. This study will allow us to continue our work on previously identified markers of arthritis risk after knee joint injury. From these studies we would predict that measuring certain markers in the knee joint fluid will either detect early arthritis, or determine the risk of future OA. Some of these molecules may act as 1) predictors of progression to OA and 2) new targets for treatments in OA.
The secondary objectives are i) to test MRI scans to see how well they measure meniscal damage to the menisci and early OA of the knee; ii) to study the frequency and patterns of OA occurring after meniscal tear, for example whether certain types of meniscal tear pose a greater risk for OA and iii) to investigate whether measurement of certain biochemical molecules in the synovial fluid at baseline predict development of radiographic OA iv) and / or predicts MR-evident OA; and v) to compare the utility of 2 different patient-reported outcome measures in the long-term assessment of those with degenerative meniscal tears. Namely KOOS (Knee injury and Osteoarthritis Outcome Score) and OKS-APS (Oxford Knee Score-Activation and Participation Questionnaire)
REC name
South Central - Oxford B Research Ethics Committee
REC reference
15/SC/0551
Date of REC Opinion
21 Oct 2015
REC opinion
Favourable Opinion