MEN1 breast cancer risk in Scotland: women attitudes towards screening
Research type
Research Study
Full title
Multiple Endocrine Neoplasia type 1 (MEN1) associated moderate breast cancer risk: women’s attitudes towards the introduction of breast screening
IRAS ID
242897
Contact name
Nicola Bradshaw
Contact email
Sponsor organisation
NHS GG&C
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 3 months, 6 days
Research summary
Multiple Endocrine Neoplasia type 1 (MEN1) is a rare inherited cancer syndrome characterised by a high risk of developing primarily endocrine tumours at various sites of the body. The main clinical manifestations of MEN1 have been established for several years. These mainly include tumours of the parathyroid glands, endocrine pancreas and anterior pituitary gland, although additional endocrine glands and other organs can also be involved. Therefore, it is recommended that patients with MEN1 undergo clinical screenings on an annual basis for the detection and treatment of MEN1-related tumours in an early stage. Recently, Dreijerink et al. (2014) suggested that women with MEN1 might also be at an increased risk of early onset breast cancer. Although no other research has been published, three independent MEN1 cohorts from France, Tasmania and the United States seem to validate this clinical observation. Thus, there is currently discussion as to whether additional screening should be recommended for this group of patients. Considering the potential need of changing the current MEN1 clinical guidelines, the purpose of this research study is to explore the effect of introducing early breast cancer surveillance amongst women with MEN1 who are mainly unaware of this risk and already attend for multiple screening investigations. To explore this, this study will use a qualitative approach based on thematic analysis and collected data using individual semi-structured interviews with 8-10 patients. Dreijerink, K. M., Goudet P., Burgess J. R and Valk G. D. (2014) International Breast Cancer in MEN1 Study Group. Breast-cancer predisposition in multiple endocrine neoplasia type 1. The New England Journal of Medicine, 371(6), pp.583–584.
REC name
West of Scotland REC 3
REC reference
18/WS/0092
Date of REC Opinion
29 Jun 2018
REC opinion
Further Information Favourable Opinion