Medicines Management in Neuropathic Pain
Research type
Research Study
Full title
Pharmacological management of neuropathic pain in primary care settings in the United Kingdom: exploring the experiences of prescribers and patients.
IRAS ID
256070
Contact name
Comfort C.D. Mshelia
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 5 months, 18 days
Research summary
Neuropathic pain, NP, which is pain arising due to injury to the nerves, affects about 8% of people in the UK. There are different types of NP depending on which part of the nervous system is affected. There is no cure for NP; people who get it will likely have it for the rest of their lives. Medicines can be used to manage the symptoms of NP and reduce the pain they feel. Although many different classes of medicines that have been shown to be effective in the management of NP, 20-40% of patients either experience less than 30% reduction in their pain or have unbearable side effects.
Previous studies exploring prescribing patterns for this group of patients in the UK have shown that prescribers often switch patients to other classes of medicines several times before a suitable treatment is found. In addition to this, there is a heavy dependence on analgesics such as Non-steroidal Anti-inflammatory Drugs, NSAIDs, and opioids even though there is no strong evidence of their usefulness in managing NP. The recent rise in the risk of addiction to Gabapentinoids including gabapentin and pregabalin as well as increasing deaths associated with these medicines, especially when the patient takes opioids as well raises concerns regarding the prescribing of these medicines for patients with NP.
There is therefore a need to undertake this study, to update our knowledge on the prescribing patterns and use of medicines used to manage NP conditions with a view to highlighting areas for improvement of prescribing practices as well as patient use in order to increase patient safety.
This study described in the following sections is the qualitative arm of a mixed methods PhD project. The quantitative arm, which comprises of analysis of prescribing data, will be undertaken concurrently.REC name
South Central - Hampshire B Research Ethics Committee
REC reference
19/SC/0526
Date of REC Opinion
5 Nov 2019
REC opinion
Further Information Favourable Opinion