MEDICI
Research type
Research Study
Full title
Mammographic Predictors of Cancer Recurrence after Breast Conservation and Adjuvant Endocrine Therapy
IRAS ID
260722
Contact name
Kulsam Ali
Contact email
Sponsor organisation
University of Dundee
Clinicaltrials.gov Identifier
v 1.1 06/06/2019, protocol approved by sponsor
Duration of Study in the UK
3 years, 8 months, 31 days
Research summary
Female hormones can help some breast cancers to grow. So most women who have had breast cancer are put on endocrine therapy such as tamoxifen which stops oestrogen from helping the cancer to grow. However in some women the cancer comes back while they are on endocrine therapy. Often we learn too late that the
treatment wasn’t working so we need to know much sooner whether it’s effective.
We can tell from mammograms how dense a woman’s breast tissue is. For some women their breasts become less dense while they are on endocrine therapy. We think that might mean that the treatment is working. We think if a woman’s breasts remain dense while on treatment, her cancer may be more likely to come back. The
aim of this study is to prove whether a reduction in breast density really does mean that the endocrine therapy is keeping the cancer away.
We have identified 2500 women who have been recruited into a research project called Mammo50. These women are all over 53 years old, have had a lump removed. 2000 are on endocrine therapy and did not have chemotherapy. We want to transfer their mammograms to a central imaging centre and use a computer and radiologists to assess if the breast tissue has become more or less dense. (We will also look at mammograms from 500 similar women who did not have endocrine therapy as a control group). The progress of these women is then followed so that we will then see if a change in density of the breast tissue is related to the effectiveness of the endocrine therapy.REC name
West of Scotland REC 4
REC reference
19/WS/0112
Date of REC Opinion
12 Aug 2019
REC opinion
Favourable Opinion