Medication and Kidney Impairment - V1_00
Research type
Research Study
Full title
Optimising kidney care: using health informatics to understand medication in kidney patients
IRAS ID
244756
Contact name
Lina Altayeb
Contact email
Sponsor organisation
University of Aberdeen
Clinicaltrials.gov Identifier
NHS National Services Scotland- eDRIS, 1718-0260
Duration of Study in the UK
2 years, 4 months, 31 days
Research summary
Prescribing of medicines is increasing and has high associated spending nationally and worldwide. Medicines are used to relieve symptoms and treat (or prevent) disease, yet they can cause harmful effects (including hospitalisation or death). As the population ages, effective and safe healthcare is a huge priority. For some medicines, safety and effectiveness in people who are not in clinical trials only slowly becomes clear. Specifically, medicines’ effects on kidney function and vice-versa - kidney function effects on medicines safety and effectiveness is often unclear initially. The kidneys play a vital role in getting rid of many drugs from the body and so poor kidney function can allow medicines’ to build up and potentially cause harm. This study will use ~500,000 Grampian residents’ records anonymously (data linked from 2004-2017 on kidney function, illnesses and prescribed medicines) to explore the relationship between prescribing patterns and new kidney impairment (whether acute or chronic). Also prescribing patterns based on kidney function level and safety or effectiveness events will be explored. This will identify areas for improvement to ensure prescribed medicines have the desired effect and avoid undesired effects, particularly in patients at high risk of developing or already with kidney impairment.
REC name
North of Scotland Research Ethics Committee 1
REC reference
18/NS/0051
Date of REC Opinion
27 Apr 2018
REC opinion
Favourable Opinion