Mechanisms of wound healing
Research type
Research Study
Full title
AN EXPLORATORY STUDY TO EVALUATE EXPRESSION AND ACTIVITY OF TRANSGLUTAMINASE-2 AND OTHER FACTORS IN SKIN WOUND HEALING IN HEALTHY PARTICIPANTS
IRAS ID
203977
Contact name
Graham Ogg
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
The study aims to investigate mechanisms of skin wound healing in order to identify new approaches to treatment of poor wound healing. Skin biopsies (samples) will be taken at different times after small skin wounds performed under local anaesthetic. 12 healthy individuals will be recruited and will be screened for eligibility, participants will be required to attend for visits over
approximately 2 weeks. The study will then examine changes in the skin as it heals. Specifically the study will investigate changes in wound healing proteins (such as transglutaminase and filaggrin) and
cells (such as immune cells). By understanding how the skin heals normally, we aim to identify approaches to modulate this process.REC name
South Central - Oxford B Research Ethics Committee
REC reference
16/SC/0457
Date of REC Opinion
19 Sep 2016
REC opinion
Favourable Opinion