Mechanisms of joint inflammation in childhood arthritis (version 1.0)
Research type
Research Study
Full title
Mechanisms of joint of inflammation in children and young people with juvenile idiopathic arthritis
IRAS ID
292585
Contact name
Adam Paul Croft
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Chronic arthritis of children, known as juvenile idiopathic arthritis (JIA), affects 1 in 10, 000 children, and is one of the leading causes of childhood-acquired disability. While some children experience self-limiting episodes of joint inflammation (pain and swelling) others develop a severe form of arthritis that can persist into adulthood. Understanding the disease mechanisms responsible for the persistence of joint inflammation will allow us to develop more targeted and effective treatments to be used early in the course of the disease, in order to prevent joint damage and disability. We now want to use ultrasound to help us to obtain synovial tissue from the lining of inflamed joints using keyhole techniques. These synovial tissue samples along with synovial fluid and peripheral blood will allow us to better understand the underlying mechanisms of disease severity, progression and treatment response.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
21/EE/0103
Date of REC Opinion
7 Jun 2021
REC opinion
Further Information Favourable Opinion