Mechanisms of Failure of Cartilage Repair Surgery
Research type
Research Study
Full title
Identifying Mechanisms of Failure of Cartilage Repair Surgery
IRAS ID
265982
Contact name
Leela Biant
Contact email
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Damage to cartilage within joints causes pain and limits the joint’s mobility. This means that people affected by cartilage damage are less able to carry out daily activities, like walking. Severe cartilage damage can be treated surgically. There are many types of cartilage repair surgery, but not all are successful. When cartilage repair surgery fails, patients are left in pain and disability. Failed cartilage repair surgeries are treated with further surgery. This is stressful for patients and expensive for the hospitals.
At the moment, we do not know why cartilage repair surgeries fail in some people and succeed in others. Because we do not have this knowledge, surgeons are not able to choose what kind of surgery would work best for each patient.This study will aim to identify how and why individual cartilage repair surgeries fail by looking at tissue samples taken from people who are having a revision surgery to treat the failure. Surgeons will be able to send tissue from donors to the University of Manchester, where the tissue will be looked at by scientists. The results will then be written up and sent back to the surgeons. The researchers will also look at groups of tissues to see if there are any trends in why the surgeries failed. This data could be used to make guidelines on which cartilage repair surgeries work best, which in turn may improve the success rates of these operations.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
19/NW/0599
Date of REC Opinion
10 Oct 2019
REC opinion
Favourable Opinion