Mechanisms of COPD Exacerbation Recurrence
Research type
Research Study
Full title
Mechanisms of COPD Exacerbation Recurrence
IRAS ID
259010
Contact name
John Hurst
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
3 years, 0 months, days
Research summary
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Patients with COPD are at increased risk of getting readmitted to hospitals within the following 30 days. Hospital readmissions of COPD contribute to clinical and economic burden on society. Understanding why some COPD patients are readmitted remains a key area of unmet need. To our knowledge, no previous study has fully investigated both the social and clinical risk factors associated with these types of patients. We want to prospectively and comprehensively explore the possible causes, whether clinical or social factors, that cause rehospitalisation. We will be collecting demographic and clinical information including daily physical activity level, lung function, blood and sputum samples. These measurements will be collected at patient admission, discharge and at follow-up of 30 and 90 days. This process could lead to a better understanding of the reasons which prevent early hospital readmission for those patients. Patients will be recruited from the Royal Free Hospital in London over a period of 18 months. We will include only patients who have a primary diagnosis of COPD and admitted to hospital with a chest infection.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
19/EM/0080
Date of REC Opinion
15 Mar 2019
REC opinion
Further Information Favourable Opinion