Mechanisms of Age-Related Clonal Haemopoiesis (MARCH)
Research type
Research Study
Full title
Mechanisms of Age-Related Clonal Haemopoiesis
IRAS ID
231756
Contact name
Niels Asger Jakobsen
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Blood cancers, such as acute myeloid leukaemia (AML), arise as a result of multiple alterations, or mutations, in genes that control blood production. AML is the most common aggressive blood cancer in adults, and unfortunately the majority of patients still die of their disease so there is a great need for better treatments.
Some of these mutations are commonly found in the blood cells of healthy older people who do not have blood cancer. This has been called Age-Related Clonal Haemopoiesis (ARCH), which is a pre-cancerous condition that increases the risk of developing blood cancers including AML. In this study, we want to investigate how mutations in blood stem cells lead to ARCH.
We will invite healthy adult volunteers undergoing hip replacement operations at the Nuffield Orthopaedic Centre in Oxford to take part in this research by donating samples of saliva, blood and bone marrow for our research. Blood and bone marrow samples will be taken during their operation and used to study the mechanisms of ARCH using cutting-edge laboratory techniques.
We expect this study to last 3 years, and hope the work will improve our understanding of how blood cancers develop in order to develop new treatments for patients with these diseases.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
17/YH/0382
Date of REC Opinion
7 Nov 2017
REC opinion
Favourable Opinion