Mechanisms of Action for Plasma Exchange in Acute Liver Failure
Research type
Research Study
Full title
Mechanisms of Action for Plasma Exchange in Acute Liver Failure (MAPLE)
IRAS ID
259081
Contact name
Joanna Moore
Contact email
Sponsor organisation
Research Governance Manager, Leeds Teaching Hospitals Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Acute Liver Failure (ALF) is a devastating condition with significant mortality. Plasma Exchange (PEX) therapy is a recognised treatment and a randomised controlled trial has shown improved outcome in patients with ALF by increasing survival. The mechanism to this benefit is not fully understood.\n\nThe primary objective is to identify which circulating proteins change in patients with ALF during and after PEX to provide insight into mechanisms of the exchange and ultimately to lead to further studies exploring the predictive potential of these proteins\n
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
19/YH/0078
Date of REC Opinion
26 Jun 2019
REC opinion
Further Information Favourable Opinion