Mechanism Study
Research type
Research Study
Full title
Muscle Epigenetic CHanges after Aerobic exercise and their association with Novel markers of Insulin Sensitivity and other Metabolic traits Study
IRAS ID
299960
Contact name
Nick Wareham
Contact email
Sponsor organisation
University of Cambridge
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
A better understanding of the epigenetic changes in skeletal muscle that are associated with obesity, insulin resistance and metabolic risk and how these are influenced by exercise may facilitate the development of more effective prevention strategies for diabetes and cardiovascular risk reduction. The Hertfordshire Physical Activity Trial offers a unique opportunity to take a systems epidemiology approach to examine the influence of a structured aerobic exercise intervention on skeletal muscle DNA methylation and gene expression, because of its large size, randomised controlled study design and detailed anthropometric and metabolic phenotyping of study participants.
REC name
West of Scotland REC 5
REC reference
21/WS/0132
Date of REC Opinion
7 Oct 2021
REC opinion
Favourable Opinion