MECANO study V2

• Research type

  Research Study

• Full title

  Metabolic biomarkers for Early Colon cancer and advanced AdeNOma Study (MECANO)

• IRAS ID

  217675

• Contact name

  James Kinross

• Contact email

  j.kinross@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Duration of Study in the UK

  5 years, 0 months, 1 days

• Research summary

  This will be a prospective, confirmatory study of a biomarker for the detection of bowel cancer. This is a blood based biomarker, based on a panel of 30 metabolites has been developed by our commercial partner, UDX (Universal diagnostics). The aim of this work is to determine if a retrospective analysis of the diagnostic accuracy of this biomarker can be reproduced in a prospective cohort. This study will determine the optimal sampling methodology, patient recruitment protocol, power and study design for a larger prospective trial. It will also perform discovery science by analysing bile acid and serum lipid metabolism in a cohort of patients with colorectal cancer. The analysis will be peformed in conjunction with the National Phenome Centre at Imperial College London.

• REC name

  London - South East Research Ethics Committee

• REC reference

  17/LO/0544

• Date of REC Opinion

  7 Jun 2017

• REC opinion

  Further Information Favourable Opinion