Measuring gut permeability in haemodialysis patients
Research type
Research Study
Full title
MEASURING GUT PERMEABILITY IN HAEMODIALYSIS PATIENTS: A PILOT STUDY
IRAS ID
190950
Contact name
Jonathan Wong
Contact email
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Patients with kidney failure and treated with dialysis are assumed to have leaky guts from in-vitro studies and animal studies however this has never been confirmed directly. This is because gut leakiness (or permeability) is conventionally measured by giving patients a special sugar solution to drink, the sugar molecules pass through the bowel wall in patients with leaky guts and can eventually detected by analysis of the urine collections. Since most dialysis patients do not pass urine, this method cannot be used. A gut permeability test has recently been developed at Maastricht University which allows gut permeability to be measured by analysis of the blood (rather than urine) for sugar molecules, this technique could potentially be used to measure gut permeability in dialysis patients.
The primary purpose of this pilot study is to determine whether this novel gut permeability test can be used to measure gut permeability in dialysis patients. Other objectives of the study include: -
1. Determing the optimum blood sampling times and the minimum number of blood samples required to detect increased gut permeability in dialysis patients.
2. Determine the impact of a single haemodialysis session on gut permeability.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
15/EE/0379
Date of REC Opinion
19 Nov 2015
REC opinion
Further Information Favourable Opinion