Measurement of O3FA levels in ileostomy fluid
Research type
Research Study
Full title
A pilot study to measure omega-3 fatty acid levels in terminal ileal content following four weeks of omega-3 fatty acid supplementation in patients with a temporary ileostomy.
IRAS ID
182428
Contact name
MA Hull
Contact email
Sponsor organisation
Faculty of Medicine and Health Reaearch Office, University of Leeds
ISRCTN Number
ISRCTN14530452
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Oily fish such as mackerel contain natural omega-3 fatty acids (O3FAs)including eicosapentaenoic acid(EPA) and docosahexaenoic acid (DHA). O3FAs are commonly used as nutritional supplements in capsule form. Scientific evidence suggests numerous health benefits including maintenance of a healthy heart and even possible anticancer effects. \n\nO3FAs are absorbed mainly within the small intestine. However there is a lack of data regarding the proportion of O3FAs that enter the large intestineand whether this is explained by direct trans ition of O3FAs through the small intestine into the colon, or whether it is secondary to shedding of cells lining the small intestine that have incorporated O3FAs following systemic distribution of O3FA. This is of increasing interest when considering the potential effect of O3FAs on the bacteria within the gut and the role of O3FAs in colorectal cancer chemoprevention. \n\nWe plan a pilot study to measure O3FA levels in ileostomy content after 4 weeks O3FA supplementation with two O3FA capsules twice daily (total dose 2000 mg EPA/DHA) in patients who have a temporary ileostomy following anterior colonic resection for colorectal cancer.\n\nIndividuals with a temporary loop ileostomy have been identified as an appropriate group of patients as terminal ileal content is accessible non-invasively from a stoma. These individuals also have an intact small bowel which is most likely to reflect the small bowel in healthy individuals. \n\nThe duration of the study is 4 weeks. Participants will be asked to provide stoma fluid samples at three separate visits. The initial and final visit will take place at St James’ University Hospital. A second stoma fluid sample will be collected at either the participants home or at hospital depending on personal preference. A blood sample will be collected at the initial and final visits in order to measure O3FA levels in the blood. \n
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
15/YH/0547
Date of REC Opinion
5 Jan 2016
REC opinion
Further Information Favourable Opinion