Measurement Of NT-proBNP to predict Outcomes in Surgery (MOBOS)
Research type
Research Study
Full title
Perioperative Measurement of NT-proBNP to Predict Outcomes in Patients Undergoing Elective Vascular Surgery
IRAS ID
260029
Contact name
Emma Miler
Contact email
Sponsor organisation
Norfolk and Norwich Univsity Hospital NHS Foundation Trust
Duration of Study in the UK
2 years, 6 months, 0 days
Research summary
The blood test N-terminal pro B-type natriuretic peptide (NT-proBNP) is currently used as a marker to decide which patients are at high risk of heart failure and should be referred to cardiology to have an echocardiogram (an ultrasound of the heart to test for heart failure).
There is evidence to suggest that this marker may be useful in predicting outcomes for patients undergoing vascular surgery. By measuring NT-proBNP before and after their surgery, we may be able to determine which patients are at risk of an adverse outcome, such as a heart attack or death.
To test this theory at the Norfolk and Norwich Hospital (NNUH), we aim to collect blood samples from 200 patients undergoing vascular surgery. The blood samples will be tested for NT-proBNP and some other cardiac markers on a machine in the Biochemistry department at the NNUH.
We will then review the outcome of each patient by determining whether or not they have had an adverse outcome following their surgery. Each patient who agrees to take part in the study will be followed up for 18 months after their surgery.
The data collected will be analysed and we will determine whether there is any relationship between NT-proBNP result and patient outcome.
If there is significant evidence to support that this test can predict risk of an adverse outcome, then the doctor can monitor patients who are at a higher risk more carefully, e.g. by having a longer stay in hospital, or be given stronger drugs.
If feasible, we will look at ways to put a clinical pathway in place for vascular surgical patients, so high-risk and low-risk patients can be identified and treated accordingly. We are hoping that this project will improve a significant number of patients’ lives for those having vascular surgery in the future.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
19/NE/0262
Date of REC Opinion
2 Aug 2019
REC opinion
Favourable Opinion