MD PAEDIGREE Cardiomyopathies
Research type
Research Study
Full title
EVALUATION OF PREDICTORS OF CARDIAC FAILURE IN CHILDREN AND ADOLESCENTS WITH CARDIOMYOPATHY
IRAS ID
151301
Contact name
Andrew Taylor
Contact email
Sponsor organisation
UCL Great Ormond Street Institute of Child Health
Research summary
This study has been set up by the European Commission as part of a larger project looking at new ways of delivering better health care for children.
Children in a number of European countries, including Italy, Germany and the UK, are taking part.
This project aims to collect information from the cardiovascular system (heart and blood vessels) and use this to predict which children will need more aggressive treatment, such as a heart transplant.
We will use many different ways of evaluating the disease severity, including echocardiogram (ultrasound scan of the heart), cardiac magnetic resonance imaging (CMR), blood pressure monitoring, clinical assessment and exercise testing to build computer models to help with these predictions. We will also look at how well we can predict the outcomes by following patients over time (18 months follow-up).
We will do some blood tests which have been seen to help prediction in adult patients with heart failure as well as looking at the genes of patients with heart failure to see if these are different from other children. We will also look at the patients’ genes to see whether any of the reasons for heart failure are inherited.
This research should help us to predict which children will become seriously ill and need more help during their illness. It may help us to prevent serious complications by starting aggressive treatment earlier in this group of patients.REC name
London - Hampstead Research Ethics Committee
REC reference
14/LO/1582
Date of REC Opinion
30 Sep 2014
REC opinion
Further Information Favourable Opinion