MC-1 Status with Age Using PET
Research type
Research Study
Full title
Evaluation of the Effects of Age on Mitochondrial Complex 1 Status
IRAS ID
220001
Contact name
Eugenii Rabiner
Contact email
Sponsor organisation
AbbVie
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
We will explore the function of mitochondria (the cell’s “power stations”) in people of various ages. Mitochondrial function is thought to decline with age and disease. We want to see what happens to the mitochondria in healthy people with increasing age, and we will use PET scanning to non-invasively look at the mitochondria in the brains of healthy individuals of various ages. PET scanning is a technique that uses very low amounts of radioactively labelled ligands (molecules used to “tag” a specific protein) to image the body. In this study we will use the ligand [18F]BCPP-FE to label a protein complex in the mitochondria, called Mitochondrial Complex 1.
Up to 24 healthy volunteers aged between 20 to 85 years will attend 2 or 3 study visits. All subjects will attend for a screening visit. Up to 5 subjects will receive two [18F]BCPP-FE PET scans. The rest will receive one [18F]BCPP-FE PET scan. All subjects will will also receive an MRI scan of the brain (which examines brain
structure using non-radioactive methods, and is used to help analyse the PET scans).The maximal amount of blood collected over the whole study will not exceed 500ml – similar to the amount collected when donating blood. The imaging will be performed at Imanova, an imaging centre jointly owned by Imperial, King’s and University Colleges and the Medical Research Council, and is part of a collaboration called MIND-MAPS between Imanova, Imperial and King’s Colleges, London and a pharmaceutical company (Abb Vie Inc.), designed to investigate new methods to detect neurodegeneration. Other studies funded by collaboration will examine patients with Alzheimer’s and Parkinson’s diseases and other molecular targets. All data collected will be published and made available to academic researchers.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
17/EE/0028
Date of REC Opinion
6 Apr 2017
REC opinion
Further Information Favourable Opinion