MASSVIP Version 1.2
Research type
Research Study
Full title
Moderate Aortic Stenosis, Symptoms and Ventricular Involvement in Progression (MASSVIP)
IRAS ID
207395
Contact name
Sveeta Badiani
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Aortic valve narrowing, or stenosis (AS) is the most common primary valve disorder and leads to symptoms such as chest pain, breathlessness or loss of consciousness. Usually, no treatment is required unless the stenosis becomes severe and the patient develops symptoms. However, patients may still have symptoms with a lesser degree of valve narrowing (moderate). Current criteria are incomplete; whilst they appreciate that AS is a disease of valve and myocardium, myocardial impairment, like symptoms, may manifest during exercise first. Secondly, our understanding under-appreciates the variety of disease development trajectories. Thirdly, we rarely objectify symptoms by quantifying cardiopulmonary limitation.
Exercise echocardiography and cardiopulmonary exercise testing can be used to establish how the heart muscle responds to exercise. We want to study 25 patients with moderate aortic stenosis and compare them to 25 age and gender matched controls and use these techniques, to determine the extent of symptom limitation. We will back up our impressions by examining heart distress using measurable blood biomarker (troponin T, NTproBNP and soluble ST2).
We will objectify symptoms in “moderate AS” and track disease development of gradient, rest and stress myocardial function. In 25 cases and 25 controls, we will measure cardiopulmonary limitation with simultaneous exercise echocardiography for valve and muscle.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
19/WM/0243
Date of REC Opinion
10 Oct 2019
REC opinion
Further Information Favourable Opinion