MASCOT v1.0
Research type
Research Study
Full title
Manometry versus Clinical Assessment in the detection of Trapped Lung in patients with Suspected Pleural Malignancy
IRAS ID
193050
Contact name
Kevin Blyth
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 8 months, 30 days
Research summary
Malignant pleural effusion (MPE) is a collection of fluid around the lung due to cancer. It is common and often causes breathlessness and hospital admission. MPE can be treated by either insertion of a chest drain (ICD) to fluid followed by injecting talc down the drain (known as pleurodesis), which prevents recurrence of MPE in 70-80%, or indwelling pleural catheter (IPC) insertion (which allows patients to have fluid drained intermittently at home). Both are equally as effective at relieving breathlessness. For pleurodesis to have a lasting effect, the lining of the lung and the lining inside the ribcage need to be in contact. In about 20% of cases, the lung does not re-expand after fluid is removed and so pleurodesis does not work. This is called trapped lung (TL).\n\nEarly detection of TL would avoid unecessary days in hospital to attempt talc pleurodesis and allow adequate time to plan for an IPC insertion. Current methods used to predict TL with scans and the appearance of the lung surface using a camera test (thoracoscopy) have been shown to be inaccurate. Measuring pressure as pleural fluid is drained (pleural manometry) is thought to be a better test for predicting TL. This can be done during routine testing without introducing another procedure for the patient. Previous studies have shown that if the pressure measurements drop quickly as fluid is removed then the lung is very likely to be trapped.\n\nThe aim of this study is to test whether using pleural manometry using a specifically designed device improves our ability to predict TL. The study will also use magnetic resonance (MRI) scans to see if MRI measurements of the amount of fluid in the chest match up as expected with the amount of fluid removed and look for new non-invasive ways of detecting TL.
REC name
West of Scotland REC 3
REC reference
16/WS/0090
Date of REC Opinion
24 May 2016
REC opinion
Further Information Favourable Opinion