Mapping Disease Pathways of Biliary Atresia
Research type
Research Study
Full title
Mapping Disease Pathways of Biliary Atresia
IRAS ID
233106
Contact name
Anil Dhawan
Contact email
Sponsor organisation
Children's Hospital of Pittsburgh of UPMC
Duration of Study in the UK
1 years, 10 months, 4 days
Research summary
The overall objective of this proposal is to map developmental/genetic disease pathways for biliary atresia (BA), the most common cause of liver failure at birth, and the most common cause of liver transplantation in children, worldwide. The etiology of BA is not known. If known, novel preventive and management strategies may be devised to reduce the societal impact of this rare childhood disease, which is fatal without surgical correction. A second objective of this proposal is to determine whether candidate genes and related pathways which predispose to BA, also predispose to congenital heart disease, or vice versa. Stored liver tissue, of those patients with BA, will be sent to Children's Hospital of Pittsburgh in the United States for DNA and mRNA extraction and ultimately, analysis.
REC name
London - City & East Research Ethics Committee
REC reference
19/LO/1103
Date of REC Opinion
27 Aug 2019
REC opinion
Further Information Favourable Opinion